Apparently, males had more large nevi than females. Accepted June 21, These results reinforce the hypothesis by which childhood would be a decisive period for the occurrence of sun-induced biological events implicated in the genesis of cutaneous melanoma. Neither the European Commission nor any person acting on its behalf is liable for any use made of the content of this article. Each lesion and diagnosis is clearly illustrated, now with more than new, digitally enhanced full-color photomicrographs and over tables. The traditional religious costume of Hutterite children protects them from sun exposure, and thus in this population, gender difference in clothing or in sun exposure habits can hardly explain gender differences observed in body site nevus distribution. Since , the greatest increase in cutaneous melanoma incidence in fair-skinned males took place on the trunk and on the head and neck, whereas in females, it took place on the limbs, mainly on the lower limbs.
The fact that we found gender to be a predictor of the body site development of small, but not of large nevi, supports the hypothesis by which small nevi and large nevi would be related to different biological events involved in the genesis of melanoma. Sex differences in sun exposure behaviors, dressing, and clothing would just add their effects to the sex-dependent inherited propensity to develop nevi on a given body site. Alike the Australian study in schoolchildren 15 , we found a larger number of large nevi in boys than in girls, but because the number of large nevi is strongly linked to the number of small nevi, adjustment on small nevus numbers cancelled most of the gender influence on large nevus counts. This article must therefore be hereby marked advertisement in accordance with 18 U. Each lesion and diagnosis is clearly illustrated, now with more than new, digitally enhanced full-color photomicrographs and over tables. For explaining the gender difference in anatomic distribution of melanoma, gender differences in sun exposure behaviors and in dressing and clothing styles have been evoked e. Our results are comparable to those from studies in Australian adolescents and schoolchildren that found significantly larger numbers of small nevi on the back 14 , 15 and on the head and neck 14 of males, whereas larger number numbers of small nevi were observed on female lower limbs Anatomic site distribution, histologic types, and comparison with non-melanoma skin cancer. The sex differences in small nevus distribution in schoolchildren reflect the sex differences in the anatomic distribution of melanoma in adults. But because i the number of small nevi is a strong predictor of the number of large nevi 12 and ii that most large nevi are located on the trunk and shoulders 13 , adjusting for small nevi decreased the apparent association between male gender and the number of large nevi. Cancer Causes Control ;5: Apparently, males had more large nevi than females. Information about each holiday period since birth to interview was recorded from parents of six hundred twenty-eight 6- to 7-year-old children in four European cities Brussels Belgium , Bochum Germany , Lyons France , and Rome Italy. The gender difference we found in numbers of nevi 2 to 4. We further hypothesize that the likelihood for a melanocyte situated in a given anatomic site to develop into a small nevus is also influenced by gender. A corresponding precis, or concise description of the clinical features, histopathology, differential diagnosis, and outstanding characteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. Show more authors Abstract Since , the greatest increase in cutaneous melanoma incidence in fair-skinned males took place on the trunk and on the head and neck, whereas in females, it took place on the limbs, mainly on the lower limbs. Since , the greatest increase in cutaneous melanoma incidence in fair-skinned males took place on the trunk and on the head and neck, whereas in females, it took place on the limbs, mainly on the lower limbs. On the one hand, in our effort to interpret this finding, we thought it could be attributed to the fact that boys at these ages usually uncover the upper part of the body when playing outdoors during spring and summertime in Greece, while prepubertal girls do not. Boys ages 5 to 6 years had significantly more small nevi Studies in European and in Australian children confirmed the site-specific differences in proliferation potential of melanocytes 13 , However, previous reports on data used in this study showed no significant gender difference in sun exposure, sunburn history during and outside holiday periods , sun protection habits, sunscreen use, and wearing of clothes when in the sun 11 , 12 , The successful focus and format of the first edition have been preserved. Solar and ultraviolet radiation. Studies with the Swedish Cancer Registry showed that before 20 years old, melanoma occurrence is more frequent on upper and lower limbs in females, whereas in males, it is more frequent on the trunk Br J Cancer ; Do you want to read the rest of this article?
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